We present the scalable fabrication of a novel transparent heater (TH) architecture by continuously creating metallic micromesh patterns on a flexible substrate via Photo Roll Lithography (PRL). The optimal TH structure is explored by systematically investigating the heating and transmittance characteristics depending on the metal material, thickness, and micromesh dimension. The transmittance is further enhanced by incorporating the biomimetic moth-eye anti-reflection layer (ARC) which effectively reduces the reflection along with diffraction and scattering of incident light. The fabricated ARC-integrated TH exhibits an excellent transmittance with satisfactory heating up to 47.5oC at the applied current of 0.6 A, which demonstrates ten times more power-efficient than conventional macroscale wire defrosters used in most vehicles. Successful defrosting of both planar and curved large-area surfaces is visually demonstrated by attaching the 70 × 70 mm-sized THs fabricated on a glass or flexible polymer. This versatile, highthroughput TH architecturing may be applicable to many other devices requiring flexibility, scalability, and power-efficient operation, and their commercially-feasible production.